Contemporary Materials II−1 (2011)
Contemporary Materials II−1 (2011) Page 55 of 61
UDK 549.68
Synthesis and X-ray cRYSTAL STRUCTURE of a copper(II) complex with pyridoxAL-aminoguanidine (plag) LIGAND
V. Jevtović1,*, D. Vidović2, S. Ivković1,3
1 University of Novi Sad, Faculty of Sciences, Department of Chemistry, Trg D. Obradovića 3, 21000 Novi Sad, Serbia
2 Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK
3 University Educons, Faculty of Environmental governance and corporate responsibility, Vojvode Putnika bb, 21208 Sremska Kamenica, Serbia
Abstract
With the reaction of warm water mixture of pyridoxal hydrochloride (PL.HCl), and Aminoguanidine-hydrogencarbonate (AG.H2CO3) in presence of Na2CO3·10H2O, pyridoxal-aminoguanidine (PLAG; H2L) was obtained. Ligand and appropriate salt CuCl2 are coordinate, and form the following complex: green-brown, hexa-coordinated, octahedral structure, dimmer-complex Cu(II) formula [Cu(PLAG)(NCS)2]2. This paper presents a synthesis and crystal structure of complex with Schiff-based ligand.
Keywords: pyridoxal-aminoguanidine Cu(II) complex, synthesis, crystal structure.
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[3] I. Giardino, A.K. Fard, D.L. Hatchell, M. Brownlee, Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation and oxidant-induced apoptosis, Diabetes 47 (1998) 1114−1120.
[4] S.H. Ihm, J.H. Yoo, S.W. Park, J. Ihm, Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats, Metabolism 48 (1999) 1141−1145.
[5] T. Taguchi, M. Sugiura, Y. Hamada, I. Miwa, Inhibition of advanced protein glycation by a Schiff base between aminoguanidine and pyridoxal, Eur. J. Pharmacol. 378 (1999) 283−289.
[6] T. Taguchi, M. Sugiura, Y. Hamada, I. Miwa, In Vivo Formation of a Schiff Base of Aminoguanidine with Pyridoxal Phosphate, Biochem. Pharmacol.55 (1998) 1667−1671.
[7] H. Miyoshi, T. Taguchi, M. Sugiura, M. Takeuchi, K. Yanagisawa, Y. Watanabe, I. Miwa, Z. Makita, T. Koike, Aminoguanidine Pyridoxal Adduct is Superior to Aminoguanidine for Preventing Diabetic Nephropathy in Mice, Horm. Metab. Res. 34 (2002) 371−377.
[8] A.S. Chen, T. Taguchi, S. Aoyama, M. Sugiura, M. Haruna, M.W. Wang, I. Miwa, Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine, Free Radical. Bio. Med. 35 (2003) 1392−1403.
[9] D.L. Price, P.M. Rhett, S.R. Thorpe, J.W. Baynes, Chelating Activity of Advanced Glycation End-product Inhibitors, J. Biol. Chem. 276 (2001) 48967−48972.
[10] V. M. Leovac, M. D. Joksovic, V. Divjakovic, Lj. Jovanovic, Z. Saranovic, A. Pevec, Synthesis, spectroscopic and X-ray characterization of a copper(II) complex with the Schiff base derived from pyridoxal and aminoguanidine: NMR spectral studies of the ligand, J. of Inorg. Bioch. 101 (2007) 1094−1097.
[11] Z. Otwinowski, W. Minor, in Methods Enzymology, edited by C.W. Carter and M.R. Sweet Academic Press, New York, USA 1996.
[12] Nonius, Delft B V, The Netherlands, 1997.
[13] A. Altomare, G. Cascarano, C. Giacovazzo, A. Guagliardi, M.C.Burla, G. Polidori, M. Camalli, SIR 92-a program for automatic solution of crystal structures by direct methods, J Appl Crystallogr. 27 (1994) 435.
[14] P.W. Betteridge, J.R. Carruthers, R.I. Cooper, J. Prout, D.J. Watkin, CRYSTAL version 12: software for guided crystal structure analysis, J App Crystallogr 36 (2003) 1487.
[15] V. Jevtovic, Cu, Fe, Ni and V complexes with pyridoxal semicarbazones. Syntheses, physical and chemical properties, structural analyses and biological activities, Monograph, Lambert Academic Publishing, Germany (2010).