Садржај


Contemporary Materials I−1 (2010)

Contemporary Materials, I–1 (2010)     Page 80 - 86

UDK 621.357:669.018

On Some Quantum Approaches to Biomolecular Recognition

D. Raković1, M. Dugić2, J. Jeknić-Dugić3, M. Plavšić4, G. Keković5, D. Davidović6,7, S. Jaćimovski8, J. Šetrajčić9,10, B. Tošić9,11, I. Cosic7, L. A. Gribov12

1 Faculty of Electrical Engineering, University of Belgrade, Serbia
2 Faculty of Science, University of Kragujevac, Serbia  
3 Faculty of Science, University of Niš, Serbia
4 Faculty of Technology and Metallurgy, University of Belgrade, Serbia  
5 Biological Institute, University of Belgrade, Serbia
6 Vinca Institute, University of Belgrade, Serbia
7 School of Electrical and Computer Engineering, RMIT, Melbourne, Australia
8 Crime-Police Academy, Belgrade, Serbia
9 Faculty of Science, University of Novi Sad, Serbia
10 Academy of Sciences and Arts of the Republic of Srpska, Banja Luka, BiH
11 Vojvodina Academy of Sciences and Arts, Novi Sad, Serbia
12 V. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS, Moscow, Russia

Abstract

Two un­re­sol­ved is­su­es of the (se­mi)clas­si­cally ad­dres­sed pro­blems in mo­le­cu­lar bi­ophysics are unre­a­so­nably long ti­me ne­ces­sary for chan­ge of bi­o­polymer con­for­ma­ti­ons and long-ran­ge directedness of se­lec­ti­ve bi­o­mo­le­cu­lar re­cog­ni­tion pro­ces­ses – implying the­ir es­sen­tial qu­an­tum origin. In this pa­per, se­ve­ral pos­si­ble qu­an­tum ap­pro­ac­hes to biomo­le­cu­lar re­cog­ni­tion are considered: The­ory of Non-Ra­di­a­ti­ve Re­so­nant Struc­tu­ral Tran­si­ti­ons, Mo­del of Qu­an­tum Decoheren­ce, and Re­so­nant Re­cog­ni­tion Mo­del. The­se appro­ac­hes might be of fun­da­men­tal importan­ce in un­der­stan­ding un­derlying mac­ro­sco­pic qu­an­tum-ho­lo­grap­hic Hop­fi­eld-li­ke con­trol mec­ha­nisms of morp­ho­ge­ne­sis, and the­ir backward in­flu­en­ce on the ex­pres­si­on of ge­nes, with signi­fi­cant po­ten­tial psycho­so­ma­tic im­pli­ca­ti­ons.

Keywords: Bi­o­mo­le­cu­lar Re­cog­ni­tion, Con­for­ma­ti­o­nal Tran­si­ti­ons, Qu­an­tum Bi­ophy­sics, Qu­an­tum Bi­o­in­for­ma­tics.

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References

[1] M. V. Volkenshtein, Biophysics, Mir, Moscow 1983.
[2] C. Levinthal, Are there pathways for pro-tein folding? J. Chim. Phys., Vol. 65 (1968) 44-45.
[3] D. Raković, Integrative Biophysics, Quantum Medicine, and Quantum-Holographic Informatics: Psychosomatic-Cognitive Implications, IASC & IEPSP, Belgrade 2009; D. Raković, Fundamentals of Biophysics, 3rded, IASC & IEFPG, Belgrade 2008, in Serbian; and refs therein.
[4] D. Raković, B. Tošić, S. Jaćimovski, J. Šetrajčić, Biomolecular recognition: On possible quantum approaches, NBP Journal of Criminalistics and Law (Belgrade), Vol. 14 (1) (2009) 33-46.
[5] L. A. Gribov, From Theory of Spectra to Theory of Chemical Transformations, URSS, Moscow 2001, in Russian.
[6] D. Raković, M. Dugić, M. Plavšić, The polymer conformational transitions: A quantum decoherence approach, Mater. Sci. Forum Switzerland, Vols. 453-454 (2004) 521-528; M. Dugić, D. Raković, M. Plavšić, The polymer conformational stability and transitions: A quantum decoherence theory approach, In: A. Spasić, J-P. Hsu (Eds.), “Finely Dispersed Particles: Micro-, Nano-, and Atto-Engineering”, CRC Press, New York 2005, 217-232; D. Raković, M. Dugić, M. Plavšić, Biopolymer chain folding and biomolecular recognition: A quantum decoherence theory approach, Mater. Sci. Forum Switzerland, Vol. 494 (2005) 513-518; D. Raković, M. Dugić, M. Plavšić, G. Keković, I. Cosic, D. Davidović, Quantum decoherence and quantum-holographic information processes: From biomolecules to biosystems, Mater. Sci. Forum Switzerland, Vol. 518 (2006) 485-490.
[7] J. Jeknić, M. Dugić, D. Raković, A unified decoherence-based model of microparticles in a solution, Mater. Sci. Forum Switzerland, Vol. 555 (2007) 405-410; J. Jeknić-Dugić, The environment-induced-superselection model of the large molecules conformational stability and transitions, Europ. Phys. J. D, Vol.51 (2009) 193-204; J. Jeknić-Dugić, Decoherence Model of Molecular Conformational Transitions, PhD Thesis, Faculty of Science, Kragujevac 2010, in Serbian.
[8] D. Raković, Scientific bases of quantum-holographic paradigm, Invited lecture. In: I. Kononeko (Ed.), “Proc. Int. Conf. Measuring Energy Fields”, Zavod Zdravilni gaj, Kamnik 2007, 64-71; D. Raković, A. Vasić, Classical-neural and quantum-holographic informatics: Psychosomatic-cognitive implications, In: B. Reljin, S. Stanković (Eds.), “Proc. NEUREL-2008”, IEEE Serbia & Montenegro Section, Belgrade 2008, 109-114.
[9] I. Cosic, The Resonant Recognition Model of Macro-molecular Bioactivity: Theory and Applications, Birkhauser Verlag, Basel 1997; I. Cosic, Macro-molecular bioactivity: Is it resonant interaction between macromolecules? – Theory and applications, IEEE Trans. Biomed. Eng., Vol. 41(12) (1994) 1101-1114; E. Pirogova, M. Akay, I. Cosic, Investigation of the structural and functional relationships of oncogene proteins, Proc. IEEE, Vol. 90(12) (2002) 1859-1867.
[10] V. Veljkovic, A Theoretical Approach to Preselection of Carcinogens and Chemical Carcenogenesis, Gordon & Breach, New York 1980; V. Veljkovic, M. Slavic, General model of pseudopo-entials, Phys. Rev. Lett., Vol. 29 (1972) 105-108.
[11] G. Keković, D. Raković, D. Davidović, Relevance of polaron/soliton-like transport mechanisms in cascade resonant isomeric transitions of Q1D-molecular chains, Mater. Sci. Forum Switzerland, Vol. 555 (2007) 119-124; G. Keković, Nonlinear Excitations of Polymer Structural Transitions, PhD Thesis, Faculty of Electrical Engineering, Belgrade 2007, in Serbian.
[12] D. Raković, A. Škokljev, D. Djordjević, Introduction to Quantum-Informational Medicine, With Basics of Quantum-Holographic Psychosoma-tics, Acupunctur-ology and Reflexotherapy, ECPD, Belgrade 2010, in Serbian.
[13] H. Fröhlich, Long-range coherence and energy storage in biological system, Int. J. Quantum Chem., Vol. 2 (1968) 641-649.
[14] V. Vojisavljevic, E. Pirogova, I. Cosic, The effect of electromagnetic radiation (550 – 850 nm) on l-lactatedehydrogenase kinetics, Int. J. Rad. Biol. 83 (4), 221 (2007).
PMid:17575949
[15] G. Keković, D. Raković, B. Tošić, D. Davidović, I. Cosic, Quantum-mechanical foundations of Resonance Recognition Model, Acta Phys. Polon. A, Vol. 17(5) (2010) 756-759.
[16] K. Pribram, Languages of the Brain:Experimental Paradoxes and Principles in Neuropsychology, Brandon, New York 1971; K. Pribram, Brain and Perception: Holonomy and Structure in Figural Processing, Lawrence Erlbaum, Hillsdale, NJ 1991.