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Contemporary Materials I−1 (2010)

Contemporary Materials, I–1 (2010)     Page 51 - 60

UDK 616–001:004.4

CHARACTERISTICS OF BIOLOGICAL MEMBRANES AND COMPUTER MODELING

M. Kojić,1,2,3,4, I. Vlastelica,5,6 B. Stojanović,3,7 V. Ranković,3 A. Tsuda1

1  Harvard School of Public Health Harvard University, 677 Huntington Avenue, MA 02115, Boston, USA
2  Department of Nanomedicine and Biomedical Engineering, University of Texas Medical Center at Houston, Houston, USA
3  Research and Development Center for Bioengineering, Sretenjskog ustava 27, 34000 Kragujevac, Serbia
4  University of Kragujevac, Kragujevac, Serbia
5  High School, Čačak, Serbia
6  Metropolitan University, Belgrade, Serbia
7  Faculty of Science, University of Kragujevac, Kragujevac, Serbia

Abstract

Mec­ha­ni­cal cha­rac­te­ri­stics of bi­o­lo­gi­cal mem­bra­nes are very im­por­tant in functi­o­ning of so­me human or­gans. A typi­cal exam­ple is lung mic­ro­struc­tu­re which represents an al­ve­o­la­ted system whe­re the gas ex­chan­ge oc­curs at the sur­fa­ce of biological mem­bra­nes. The ove­rall area of the mem­bra­ne sur­fa­ce is hu­ge and it significantly chan­ges du­ring in­spi­ra­tion-ex­pi­ra­ti­on bre­at­hing cycles. The mem­bra­nes are co­ve­red by a sur­fac­tant, a sur­fa­ce-ac­ti­ve li­po­pro­tein com­plex, vi­tally im­por­tant for the nor­mal lung fun­ction.

In this pa­per we first de­scri­be mem­bra­ne tis­sue ma­te­rial cha­rac­te­ri­stics ob­ta­i­ned by experi­men­tal in­ve­sti­ga­ti­ons and then bri­efly sum­ma­ri­ze com­pu­ta­ti­o­nal pro­ce­du­res employed for com­pu­ter mode­ling of the bi­o­lo­gi­cal mem­bra­ne mec­ha­ni­cal re­spon­se experi­en­cing lar­ge de­for­ma­ti­ons over cycling lo­a­ding. The­se pro­ce­du­res are im­ple­men­ted to a sim­ple mo­del of bi­a­xi­al cycling stretching of a bi­o­lo­gi­cal mem­bra­ne co­ve­red by surfac­tant, and with el­lip­ti­cal ho­le and a ring at the ho­le rim.

Keywords: Soft tis­sue har­de­ning cha­rac­te­ri­stics, hyste­re­sis of tis­sue and sur­fac­tant, compu­ter mo­de­ling, fi­ni­te ele­ment met­hod, stress in­te­gra­tion.

 

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